The MARCH family of RING-finger E3 ubiquitin ligases comprise 11 members that have been reported to play a variety of roles in the Socks downregulation of cell-surface proteins involved in adaptive immunity.The RING-CH domain of MARCH proteins is thought to ubiquitinate the cytoplasmic tails (CTs) of target proteins, leading to protein degradation
The aim of the work is to identify the main trends and shortcomings of the remuneration policy in the budgetary sphere of Ukraine and develop proposals for its improvement.There determined the main problems of the remuneration policy in the budgetary sphere, including the low level and unsatisfactory wage differentiation, intersectoral imbalances i
Flexible pipelines connect offshore platforms to subsea production systems due to their high flexibility, applicability, and recycling.Flexible armor layers in flexible pipelines are constructed using the parallel helical wrapping of several rectangular wires.The complex stress modes to which pipelines are subjected provide complex failure modes th
Background: Colorectal cancer is one of the most frequent cancers in developed countries and Slovenia, and the incidence is still rising.Groups of people with higher risk for colorectal cancer are well defined.Among them are patients with inflammatory bowel disease.The risk is highest in patients in whom whole large bowel is affected by inflammatio